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Job Description
General/Position Summary
The Senior Principal Research Scientist is self-reliant with a proven record of accomplishments, independently identifying and solving complex problems using sophisticated scientific methods and analytical thought, across a number of critical and diverse projects. The Senior Principal Research Scientist encourages use of diverse experimental approaches within their area of work and takes limited risks to test and advance innovative processes and methodologies that generate insights that inuence research strategies in their area of discipline. Regarded as an expert in a eld of research, providing reliable, valuable advice to other Project Teams on a regular basis.
Key Duties & Responsibilities
- Collaborate with Discovery Research team to identify new markers (intracellular and cell surface) as targets for flow cytometry assays
- Develop multiplex flow cytometry panels to characterize and quantify cell populations within expansion and differentiation phases; qualify assays as needed
- Perform bridging studies to show lab-to-lab and instrument-to-instrument comparability
- Evaluate and/or implement flow assays in automated platforms working closely with the Cell and Gene Analytical Technologies (CGAT) team
- Evaluate new multiplexing technology platforms to map differentiation states and enable analytical in process control strategy
- Makes data-driven conclusions and identies comprehensive implications for ndings
- Makes substantive contributions that impact the achievement of critical project activities and scientic strategies within discipline
- Author analytical methods (AM) and method development reports (MDR)
- Be a mentor and leader within the lab for junior scientists
- Perform routine testing as needed
- Performs other duties as assigned
Education/Experience:
Bachelor's, Master's, or PhD
Typically requires the following, or the equivalent combination of education and experience: PhD and 6-8+ years, or Master's and 9+ years, or Bachelor's and 11+ years
Required Knowledge and Skills
- Specialized depth of knowledge in stem cell biology, especially, pluripotent stem cells (PSC), such as embryonic stem cells (ESC) and induced PSCs (iPSC)-derived differentiated cells (e.g. insulin-producing cells).
- Strong flow cytometry assay development experience
- Ability to consistently advise/mentor others to execute technically challenging, complex experiments that directly impact projects and programs within discipline
- Ability to consistently identify and leverage new, productive paths/approaches in experiments
- Demonstrated initiative and ability to impact and advance projects through scientic creativity and insights
- Assigned to the more challenging or higher-value project tasks/problems
- Often will have demonstrated outstanding determination and/or persistence in supporting project(s)
- Strong communication skills with the ability to effectively write advanced technical documents, and ability to persuade others presenting technical/scientific concepts to diverse audiences
- Values team work and collaboration to solve problems and design strategies
#LI-SV1 #LI-onsite
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Human Resources at ApplicationAssistance@vrtx.com.