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St. Jude has a long history of innovation in the treatment of pediatric cancer. Less well known are the ongoing efforts to achieve better detection and classification of different types of cancer at the subclone level using computational algorithms. The importance of this work is illustrated by the recent discovery that certain chemotherapy protocols used for the treatment of pediatric Hodgkin's Lymphoma are associated with a change in the makeup of cell populations within the peripheral blood. Including genetic alterations correlated with an increased risk of breast cancer later in life.
Responsibilities
Perform accurate and precise sample processing, including RNA Isolation, DNA isolation, preparation of single cells suspensions, and archiving of material under the supervision of the operations manager.
Perform microscopic examination of tissues using H&E and process samples using platforms for spatial transcriptional and protein profiling.
Prepare libraries and perform sequencing on NGS platforms. Data types include but are not limited to WGS, RNASeq, WES, and single cell multi-omics.
Perform cell population characterization using software on the computational cluster to identify single cells with specific genotypes and cell surface markers under the direction of a senior scientist.
Preferred Skills
Experience in basic molecular biology such as PCR, QPCR, DNA isolation, and RNA isolation.
Experience in microscopy such as bright field illumination, phase contrast, Immuno-fluorescence microscopy, TIRF, and H&E.
Knowledge of basic cell culture techniques
Familiarity with Microsoft Excel, PowerPoint, and Word software.
Opportunities for Professional Growth
The selected candidate will have the opportunity to gain extensive knowledge on current and evolving methods for identifying genomic and transcriptomic variation in single cells and cell populations.
Scientist:
Minimum Education and/or Training:
- Bachelor's degree in relevant scientific area is required.
Minimum Experience:
- Seven (7) years of relevant post-degree work experience is required
- Five (5) years of relevant post-degree work experience is required with a Master's degree
- Three (3) years of relevant post-degree work experience is required with a PhD
Lead Researcher:
Minimum Education and/or Training:
Bachelor's degree in relevant scientific area is required
Minimum Experience:
Five (5) years of relevant, post-degree work experience is required
Two (2) years of relevant post-degree work experience is required with a Master's degree
No experience is required with a PHD
Compensation
In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $65,520 - $114,400 per year for the role of Scientist/ Lead Researcher - Computational Biology Genomics Laboratory.Explore our exceptional benefits!
Diversity, Equity and Inclusion
St. Jude Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay. Learn more about our history and commitment.
Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.
St. Jude is an Equal Opportunity Employer
No Search Firms
St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
St. Jude Children's Research Hospital is an Equal Opportunity Employer. St. Jude does not discriminate on the basis of race, national origin, sex, genetic information, sexual orientation, gender identity, transgender status, age, religion, disability, veteran's status or disabled veteran's status with respect to employment opportunities. All qualified applicants will be considered for employment. St. Jude engages in affirmative action to increase employment opportunities for minorities, women, veterans and individuals with disabilities.